Aiming for the pocket

Silvennoinen, O; Haikarainen, T; Virtanen, A

Silvennoinen, O (通讯作者),Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland.;Silvennoinen, O (通讯作者),Univ Helsinki, HiLIFE, Inst Biotechnol, Helsinki, Finland.

NATURE CHEMICAL BIOLOGY, 2022; 18 (12): 1296

Abstract

Isoform-selective inhibition of JAK kinases is of key interest in drug discovery. A novel pocket in the JAK pseudokinase domain was targeted by an all......

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