Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression

Jiang, Y; Wang, T; Sheng, DD; Han, CQ; Xu, T; Zhang, P; You, WY; Fan, WW; Zhang, ZY; Jin, TC; Duan, XT; Yuan, X; Liu, X; Zhang, KG; Ruan, K; Shi, J; Guo, J; Cheng, AX; Yang, ZY

Cheng, AX; Yang, ZY (通讯作者),Univ Sci & Technol China, Anhui Prov Hosp, Dept Digest Dis, Affiliated Hosp 1, Hefei, Peoples R China.;Yang, ZY (通讯作者),Univ Sci & Technol China, MOE Key Lab Cellular Dynam, Hefei, Peoples R China.;Yang, ZY (通讯作者),Univ Sci & Technol China, Biomed Sci & Hlth Lab Anhui Prov, Hefei, Peoples R China.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2022; 298 (11):

Abstract

Cancer cells have distinctive demands for intermediates from glucose metabolism for biosynthesis and energy in different cell cycle phases. However, h......

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