Multi-PGS enhances polygenic prediction by combining 937 polygenic scores

Albiñana, C; Zhu, ZH; Schork, AJ; Ingason, A; Aschard, H; Brikell, I; Bulik, CM; Petersen, LV; Agerbo, E; Grove, J; Nordentoft, M; Hougaard, DM; Werge, T; Borglum, AD; Mortensen, PB; McGrath, JJ; Neale, BM; Privé, F; Vilhjálmsson, BJ

Albiñana, C; Vilhjálmsson, BJ (通讯作者)，iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, DK-8210 Aarhus V, Denmark.;Albiñana, C; Vilhjálmsson, BJ (通讯作者)，Aarhus Univ, Natl Ctr Register Based Res, DK-8210 Aarhus V, Denmark.;Vilhjálmsson, BJ (通讯作者)，Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark.;Vilhjálmsson, BJ (通讯作者)，Broad Inst MIT & Harvard, Novo Nordisk Fdn Ctr Genom Mech, Cambridge, MA 02142 USA.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Polygenic scores (PGS) have high potential for clinical use but are currently underpowered for many applications. Here, the authors develop an approac......

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