Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

Pajares, MA; Zimmermann, T; Sanchez-Gomez, FJ; Ariza, A; Torres, MJ; Blanca, M; Canada, FJ; Montanez, MI; Perez-Sala, D

Perez-Sala, D (corresponding author), CSIC, Dept Struct & Chem Biol, Ctr Invest Biol, Madrid, Spain.; Montanez, MI (corresponding author), Hosp Civil, Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain.; Montanez, MI (corresponding author), Andalusian Ctr Nanomed & Biotechnol BIONAND, Nanostruct Diagnosing & Treatment Allerg Dis Lab, Malaga, Spain.

FRONTIERS IN PHARMACOLOGY, 2020; 11 ():

Abstract

Serum and cellular proteins are targets for the formation of adducts with the beta-lactam antibiotic amoxicillin. This process could be important for ......

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