Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility

Chen, Y; Zhu, YW; Li, X; Gao, WB; Zhen, ZQ; Dong, D; Huang, BL; Ma, Z; Zhang, AQ; Song, XC; Ma, Y; Guo, CY; Zhang, F; Huang, ZW

Huang, ZW (通讯作者)，Harbin Inst Technol, Sch Life Sci & Technol, HIT Ctr Life Sci, Harbin 150080, Peoples R China.

MOLECULAR CELL, 2022; 82 (7): 1278

Abstract

Cholesterol molecules specifically bind to the resting alpha beta TCR to inhibit cytoplasmic CD3 zeta ITAM phosphorylation through sequestering the TC......

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