Prophages are associated with extensive CRISPR-Cas auto-immunity

Nobrega, FL; Walinga, H; Dutilh, BE; Brouns, SJJ

Brouns, SJJ (corresponding author), Delft Univ Technol, Dept Bionanosci, Delft, Netherlands.; Brouns, SJJ (corresponding author), Kavli Inst Nanosci, Delft, Netherlands.; Dutilh, BE (corresponding author), Univ Utrecht, Science4Life, Theoret Biol & Bioinformat, Utrecht, Netherlands.

NUCLEIC ACIDS RESEARCH, 2020; 48 (21): 12074

Abstract

CRISPR-Cas systems require discriminating self from non-self DNA during adaptation and interference. Yet, multiple cases have been reported of bacteri......

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