Development and validation of liquid chromatography tandem mass spectrometry method quantitative determination of polymyxin B1, polymyxin B2, polymyxin B3 and isoleucine-polymyxin B1 in human plasma and its application in clinical studies

Hee, KH; Leaw, YKJ; Ong, JL; Lee, LS

Lee, LS (reprint author), Natl Univ Singapore, Dept Med, Level 10 NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2017; 140 ( ): 91

Abstract

Polymyxin B (PB) is an antibiotic consisting of a cyclic heptapeptide and a tripeptide side chain used in treatment of infections caused by Gram-negat......

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