CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation

Romer, TB; Khoder-Agha, F; Aasted, MKM; de Haan, N; Horn, S; Dylander, A; Zhang, T; Pallesen, EMH; Dabelsteen, S; Wuhrer, M; Hogsbro, CF; Thomsen, EA; Mikkelsen, JG; Wandall, HH

Wandall, HH (通讯作者),Univ Copenhagen, Copenhagen Ctr Glyc, Dept Cellular & Mol Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

GLYCOBIOLOGY, 2023; 33 (9): 700

Abstract

Introduction: In epithelial cancers, truncated O-glycans, such as the Thomson-nouveau antigen (Tn) and its sialylated form (STn), are upregulated on t......

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