Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma

Jia, YL; Zhou, JB; Tan, TK; Chung, TH; Wong, RWJ; Chooi, JY; Lim, JSL; Sanda, T; Ooi, M; De Mel, S; Soekojo, C; Chen, YX; Zhang, EF; Cai, Z; Shen, P; Ruan, J; Chng, WJ

Chng, WJ (corresponding author), Natl Univ Singapore, Ctr Translat Med, Canc Sci Inst Singapore, 14 Med Dr, Singapore 117599, Singapore.; Chng, WJ (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117597, Singapore.; Chng, WJ (corresponding author), Natl Univ Hlth Syst NUHS, Natl Univ Canc Inst Singapore NCIS, Dept Hematol Oncol, 1E,Kent Ridge Rd, Singapore 119228, Singapore.

BLOOD CANCER JOURNAL, 2021; 11 (2):

Abstract

Multiple myeloma (MM) is an aggressive plasma cell neoplasm characterized by genomic heterogeneity. Superenhancers (SEs) are defined as large clusters......

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