A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

Scott, DE; Francis-Newton, NJ; Marsh, ME; Coyne, AG; Fischer, G; Moschetti, T; Bayly, AR; Sharpe, TD; Haas, KT; Barber, L; Valenzano, CR; Srinivasan, R; Huggins, DJ; Lee, M; Emery, A; Hardwick, B; Ehebauer, M; Dagostin, C; Esposito, A; Pellegrini, L; Perrior, T; McKenzie, G; Blundell, TL; Hyvonen, M; Skidmore, J; Venkitaraman, AR; Abell, C

Skidmore, J (corresponding author), Univ Cambridge, Yusuf Hamied Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England.; Venkitaraman, AR (corresponding author), Univ Cambridge, MRC, Canc Unit, Hutchison MRC Res Ctr, Hills Rd, Cambridge CB2 0XZ, England.; Hyvonen, M (corresponding author), Univ Cambridge, Dept Biochem, 80 Tennis Court Rd, Cambridge CB2 1GA, England.; Skidmore, J (corresponding author), Univ Cambridge, ALBORADA Drug Discovery Inst, Isl Res Bldg,Hills Rd, Cambridge CB2 0AH, England.

CELL CHEMICAL BIOLOGY, 2021; 28 (6): 835

Abstract

BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually enga......

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