Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models

Schäfer, M; Reisch, F; Labuz, D; Machelska, H; Stehling, S; Püschel, GP; Rothe, M; Heydeck, D; Kuhn, H

Kuhn, H (通讯作者)，Charite Univ Med Berlin, Dept Biochem, Charitepl 1, D-10117 Berlin, Germany.;Kuhn, H (通讯作者)，Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.;Kuhn, H (通讯作者)，Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023; 24 (13):

Abstract

Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in the pathogenesis of inflammatory diseases, and its pro- and anti-inflammatory......

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