Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need

Park, M; Miyoshi, C; Fujiyama, T; Kakizaki, M; Ikkyu, A; Honda, T; Choi, J; Asano, F; Mizuno, S; Takahashi, S; Yanagisawa, M; Funato, H

Yanagisawa, M; Funato, H (corresponding author), Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, Tsukuba, Ibaraki 3058575, Japan.; Yanagisawa, M (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA.; Yanagisawa, M (corresponding author), Univ Tsukuba, Life Sci Ctr Survival Dynam, Tsukuba Adv Res Alliance TARA, Tsukuba, Ibaraki 3058575, Japan.; Funato, H (corresponding author), Toho Univ, Fac Med, Dept Anat, Tokyo 1438540, Japan.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

Although sleep is one of the most conserved behaviors, the intracellular mechanism regulating sleep/wakefulness remains unknown. We recently identifie......

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