Lysosome-targeting chimaeras for degradation of extracellular proteins

Banik, SM; Pedram, K; Wisnovsky, S; Ahn, G; Riley, NM; Bertozzi, CR

Bertozzi, CR (corresponding author), Stanford Univ, Dept Chem, Stanford, CA 94305 USA.; Bertozzi, CR (corresponding author), Howard Hughes Med Inst, Stanford, CA 94305 USA.

NATURE, 2020; 584 (7820): 291

Abstract

The majority of therapies that target individual proteins rely on specific activity-modulating interactions with the target protein-for example, enzym......

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