Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis

Li, X; Maretzky, T; Perez-Aguilar, JM; Monette, S; Weskamp, G; Le Gall, S; Beutler, B; Weinstein, H; Blobel, CP

Blobel, CP (reprint author), Hosp Special Surg, Arthritis & Tissue Degenerat Program, New York, NY 10021 USA.; Blobel, CP (reprint author), Weill Cornell Med, Dept Biochem Cellular & Mol Biol, New York, NY 10021 USA.; Blobel, CP (reprint author), Weill Co

JOURNAL OF CELL SCIENCE, 2017; 130 (5): 868

Abstract

A disintegrin and metalloproteinase 17 (ADAM17) controls the release of the pro-inflammatory cytokine tumor necrosis factor a (TNF alpha, also known a......

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