Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Hermant, P; Bosc, D; Piveteau, C; Gealageas, R; Lam, B; Ronco, C; Roignant, M; Tolojanahary, H; Jean, L; Renard, PY; Lemdani, M; Bourotte, M; Herledan, A; Bedart, C; Biela, A; Leroux, F; Deprez, B; Deprez-Poulain, R

Deprez-Poulain, R (reprint author), Univ Lille Nord France, INSERM, Inst Pasteur Lille, U1177,Drugs & Mol Living Syst, F-59000 Lille, France.; Deprez-Poulain, R (reprint author), Inst Univ France, F-75231 Paris, France.

JOURNAL OF MEDICINAL CHEMISTRY, 2017; 60 (21): 9067

Abstract

Hydroxamic acids are outstanding zinc chelating groups that can be used to design potent and selective metalloenzyme inhibitors in various therapeutic......

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