RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5 '-UTR

Yan, JX; Zhao, YF; Du, J; Wang, Y; Wang, SH; Wang, Q; Zhao, X; Xu, W; Zhao, K

Xu, W (通讯作者)，First Hosp Jilin Univ, Dept Clin Lab, Changchun, Jilin, Peoples R China.;Zhao, K (通讯作者)，First Hosp Jilin Univ, Ctr Pathogen Biol & Infect Dis, Changchun, Jilin, Peoples R China.

MOBILE DNA, 2022; 13 (1):

Abstract

Background: Type 1 long interspersed elements, or LINE-1, are the only retroelements that replicate autonomously in human cells. The retrotranspositio......

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