Mechanistic evaluation of the inhibitory effect of four SGLT-2 inhibitors on SGLT 1 and SGLT 2 using physiologically based pharmacokinetic (PBPK) modeling approaches

Zhang, Y; Xie, PP; Li, YM; Chen, ZX; Shi, AX

Shi, AX (通讯作者)，Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Clin Trial Ctr,Natl Ctr Gerontol, Beijing, Peoples R China.

FRONTIERS IN PHARMACOLOGY, 2023; 14 ():

Abstract

Sodium-glucose co-transporter type 2 (SGLT 2, gliflozins) inhibitors are potent orally active drugs approved for managing type 2 diabetes. SGLT 2 inhi......

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