Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells

Huun, J; Gansmo, LB; Mannsaker, B; Iversen, GT; Ovrebo, JI; Lonning, PE; Knappskog, S

Knappskog, S (reprint author), Univ Bergen, Dept Clin Sci, Sect Oncol, N-5020 Bergen, Norway.; Knappskog, S (reprint author), Haukeland Hosp, Dept Oncol, Bergen, Norway.

BMC CELL BIOLOGY, 2017; 18 ( ):

Abstract

Background: The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplifi......

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