Germline Elongator mutations in Sonic Hedgehog medulloblastoma

Waszak, SM; Robinson, GW; Gudenas, BL; Smith, KS; Forget, A; Kojic, M; Garcia-Lopez, J; Hadley, J; Hamilton, KV; Indersie, E; Buchhalter, I; Kerssemakers, J; Jager, N; Sharma, T; Rausch, T; Kool, M; Sturm, D; Jones, DTW; Vasilyeva, A; Tatevossian, RG; Neale, G; Lombard, B; Loew, D; Nakitandwe, J; Rusch, M; Bowers, DC; Bendel, A; Partap, S; Chintagumpala, M; Crawford, J; Gottardo, NG; Smith, A; Dufour, C; Rutkowski, S; Eggen, T; Wesenberg, F; Kjaerheim, K; Feychting, M; Lannering, B; Schuz, J; Johansen, C; Andersen, TV; Roosli, M; Kuehni, CE; Grotzer, M; Remke, M; Puget, S; Pajtler, KW; Milde, T; Witt, O; Ryzhova, M; Korshunov, A; Orr, BA; Ellison, DW; Brugieres, L; Lichter, P; Nichols, KE; Gajjar, A; Wainwright, BJ; Ayrault, O; Korbel, JO; Northcott, PA; Pfister, SM

Korbel, JO (corresponding author), European Mol Biol Lab, Genome Biol Unit, Heidelberg, Germany.; Northcott, PA (corresponding author), St Jude Childrens Res Hosp, Dept Dev Neurobiol, 332 N Lauderdale St, Memphis, TN 38105 USA.; Pfister, SM (corresponding author), Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany.; Pfister, SM (corresponding author), German Canc Res Ctr, German Consortium Translat Canc Res DKTK, Div Pediat Neurooncol, Heidelberg, Germany.; Pfister, SM (corresponding author), Heidelberg Univ Hosp, Dept Pediat Hematol & Oncol, Heidelberg, Germany.

NATURE, 2020; 580 (7803): 396

Abstract

Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of man......

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