Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists

Pogorelov, VM; Martini, ML; Jin, J; Wetsel, WC; Caron, MG

Pogorelov, VM; Wetsel, WC (通讯作者)，Duke Univ, Dept Psychiat & Behav Sci, Med Ctr, 354 Sands Bldg,303 Res Dr, Durham, NC 27710 USA.;Wetsel, WC (通讯作者)，Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA.;Wetsel, WC (通讯作者)，Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA.

BIOMOLECULES, 2023; 13 (11):

Abstract

L-DOPA is the mainstay of treatment for Parkinson's disease (PD). However, over time this drug can produce dyskinesia. A useful acute PD model for scr......

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