A kinase-independent role for CDK8 in BCR-ABL1(+) leukemia

Menzl, I; Zhang, TH; Berger-Becvar, A; Grausenburger, R; Heller, G; Prchal-Murphy, M; Edlinger, L; Knab, VM; Uras, IZ; Grundschober, E; Bauer, K; Roth, M; Skucha, A; Liu, Y; Hatcher, JM; Liang, YK; Kwiatkowski, NP; Fuxl, D; Hoelbl-Kovacic, A; Kubicek

Sexl, V (reprint author), Univ Vet Med, Inst Pharmacol & Toxicol, Vienna, Austria.

NATURE COMMUNICATIONS, 2019; 10 ():

Abstract

Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key rol......

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