Adaptive two-stage optimal designs for phase II clinical studies that allow early futility stopping

Shan, GG; Zhang, H; Jiang, T

Shan, GG (reprint author), Univ Nevada, Sch Publ Hlth, Dept Environm & Occupat Hlth, Epidemiol & Biostat Program, 4505 S Maryland Pkwy,Box 453064, Las Vegas, NV 89154 USA.; Jiang, T (reprint author), Zhejiang Gongshang Univ, Dept Stat, Hangzhou, Zhejiang,

SEQUENTIAL ANALYSIS-DESIGN METHODS AND APPLICATIONS, 2019; 38 (2): 199

Abstract

Adaptive designs play an important role in contemporary clinical trials to make designs flexible and efficient. In cancer clinical trials, given a rel......

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