Quadruple-editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cells

Wang, ZZ; Kang, B; Gao, QQ; Huang, L; Di, JB; Fan, YC; Yu, JH; Jiang, BH; Gao, F; Wang, D; Sun, HX; Gu, Y; Li, J; Su, XQ

Su, XQ (corresponding author), Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg 4, Beijing, Peoples R China.; Kang, B (corresponding author), BGI Shenzhen, Shenzhen, Peoples R China.; Li, J (corresponding author), Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Oncol, Beijing, Peoples R China.

CANCER SCIENCE, 2021; 112 (9): 3895

Abstract

Mutated KRAS promotes the activation of the MAPK pathway and the progression of colorectal cancer (CRC) cells. Aberrant activation of the PI3K pathway......

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