Administration in fed state but not controlled release in the colon increases oral bioavailability of DF030263, a promising drug candidate for chronic lymphocytic leukemia

Lee, JB; Zang, XW; Zgair, A; Ooi, TQ; Foley, DW; Voronin, G; Kagan, L; Soukarieh, F; Gao, R; Shao, H; Soh, WT; Kim, TH; Kim, MG; Yun, HY; Wilson, AJ; Fischer, PM; Gershkovich, P

Gershkovich, P (corresponding author), Univ Nottingham, Ctr Biomol Sci, Sch Pharm, Univ Pk, Nottingham NG7 2RD, England.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 165 (): 106

Abstract

For treatment of chronic cancers, the oral administration route is preferred as it provides numerous advantages over other delivery routes. However, t......

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