The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28

Muller, YD; Nguyen, DP; Ferreira, LMR; Ho, P; Raffin, C; Valencia, RVB; Congrave-Wilson, Z; Roth, TL; Eyquem, J; Van Gool, F; Marson, A; Perez, L; Wells, JA; Bluestone, JA; Tang, QZ

Muller, YD; Tang, QZ (corresponding author), Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA.; Muller, YD; Tang, QZ (corresponding author), Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94143 USA.; Muller, YD (corresponding author), Ctr Hosp Univ Vaudois CHUV, Dept Med Serv Immunol & Allergie, Lausanne, Switzerland.

FRONTIERS IN IMMUNOLOGY, 2021; 12 ():

Abstract

Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and ......

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