Modulation of CD47-SIRP alpha innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody

Narla, RK; Modi, H; Bauer, D; Abbasian, M; Leisten, J; Piccotti, JR; Kopytek, S; Eckelman, BP; Deveraux, Q; Timmer, J; Zhu, D; Wong, L; Escoubet, L; Raymon, HK; Hariharan, K

Narla, RK (通讯作者),Bristol Myers Squibb, 10300 Campus Point Dr,Suite 100, San Diego, CA 92121 USA.

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022; 71 (2): 473

Abstract

Cluster of differentiation 47 (CD47) is a transmembrane protein ubiquitously expressed on human cells but overexpressed on many different tumor cells.......

Full Text Link