Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles

Vermeulen, LMP; Brans, T; Samal, SK; Dubruel, P; Demeester, J; De Smedt, SC; Remaut, K; Braeckmans, K

Braeckmans, K (reprint author), Univ Ghent, Lab Gen Biochem & Phys Pharm, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.; Braeckmans, K (reprint author), Univ Ghent, Ctr Nano & Biophoton, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

ACS NANO, 2018; 12 (3): 2332

Abstract

In gene therapy, endosomal escape represents a major bottleneck since nanoparticles often remain entrapped inside endosomes and are trafficked toward ......

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