Biosynthesis of the Immunosuppressant (-)-FR901483

Zhang, Z; Tamura, Y; Tang, MC; Qiao, TZ; Sato, M; Otsu, Y; Sasamura, S; Taniguchi, M; Watanabe, K; Tang, Y

Tang, Y (corresponding author), Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA.; Tang, Y (corresponding author), Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA.; Watanabe, K (corresponding author), Univ Shizuoka, Dept Pharmaceut Sci, Shizuoka 4228526, Japan.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021; 143 (1): 132

Abstract

We report characterization of the biosynthetic pathway of the potent immunosuppressant (-)-FR901483 (1) through heterologous expression and enzymatic ......

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