Glucocorticoids delay RAF-induced senescence promoted by EGR1

Carvalho, C; L'Hote, V; Courbeyrette, R; Kratassiouk, G; Pinna, G; Cintrat, JC; Denby-Wilkes, C; Derbois, C; Olaso, R; Deleuze, JF; Mann, C; Thuret, JY

Mann, C; Thuret, JY (reprint author), Univ Paris Saclay, Univ Paris Sud, Inst Integrat Biol Cell I2BC, CEA,CNRS, F-91198 Gif Sur Yvette, France.

JOURNAL OF CELL SCIENCE, 2019; 132 (16):

Abstract

Expression of hyperactive RAF kinases, such as the oncogenic B-RAF-V600E mutant, in normal human cells triggers a proliferative arrest that blocks tum......

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