Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2

Cui, HS; Diedrich, JK; Wu, DC; Lim, JJ; Nottingham, RM; Moresco, JJ; Yates, JR; Blencowe, BJ; Lambowitz, AM; Schimmel, P

Schimmel, P (通讯作者),Scripps Res Inst, Dept Mol Med, La Jolla, CA 92037 USA.;Lambowitz, AM (通讯作者),Univ Texas Austin, Inst Cellular & Mol Biol, Dept Mol Biosci & Oncol, Austin, TX 78712 USA.

NATURE CELL BIOLOGY, 2023; 25 (4): 592

Abstract

Cui et al. find that arginine depletion and inflammation reduces nuclear localization of arginyl-tRNA synthetase, which influences alternative splicin......

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