Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader

Yu, XF; Wang, J; Gong, WD; Ma, AQ; Shen, YD; Zhang, CW; Liu, XJ; Cai, L; Liu, J; Wang, GG; Jin, J

Yu, XF; Jin, J (通讯作者)，Icahn Sch Med Mt Sinai, Tisch Canc Inst, Mt Sinai Ctr Therapeut Discovery, Dept Pharmacol Sci, New York, NY 10029 USA.;Yu, XF; Jin, J (通讯作者)，Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Oncol Sci & Neurosci, New York, NY 10029 USA.;Wang, GG (通讯作者)，Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.;Wang, GG (通讯作者)，Univ North Carolina Chapel Hill, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA.;Wang, GG (通讯作者)，Univ North Carolina Chapel Hill, Dept Pharmacol, Chapel Hill, NC 27599 USA.

ONCOGENE, 2023; 42 (13): 994

Abstract

Multiple myeloma (MM) is the second most common hematological malignancy with poor prognosis. Enhancer of zeste homolog 2 (EZH2) is the enzymatic subu......

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