Computationally Supported Inversion of Ketoreductase Stereoselectivity

Delgado-Arciniega, E; Wijma, HJ; Hummel, C; Janssen, DB

Wijma, HJ; Janssen, DB (通讯作者),Univ Groningen, Groningen Biomol Sci & Biotechnol Inst GBB, Biotransformat & Biocatalysis, Nijenborgh 4, NL-9747 AG Groningen, Netherlands.

CHEMBIOCHEM, 2023; 24 (9):

Abstract

Whereas directed evolution and rational design by structural inspection are established tools for enzyme redesign, computational methods are less matu......

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