Deciphering the resistance mechanism of RET kinase mutant against vandetanib and nintedanib using molecular dynamics simulations

Zheng, GD; Xu, SQ; Liu, WX; Du, TT; Zhang, JF; Li, MY; Cai, C; Shi, H

Cai, C; Shi, H (corresponding author), Navy Mil Med Univ, Changhai Hosp, Dept VIP Clin, Shanghai 200433, Peoples R China.

JOURNAL OF EXPERIMENTAL NANOSCIENCE, 2021; 16 (1): 279

Abstract

The RET protein is a transmembrane receptor tyrosine kinase (RTK) whose oncogenic mutations or fusions are closely related to human cancers such as th......

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