THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate

Polenkowski, M; Allister, AB; de Lara, SB; Pierce, A; Geary, B; El Bounkari, O; Wiehlmann, L; Hoffmann, A; Whetton, AD; Tamura, T; Tran, DDH

Tran, DDH (通讯作者)，Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30623 Hannover, Germany.;Tran, DDH (通讯作者)，Hannover Med Sch, Inst Zellbiochemie, D-30623 Hannover, Germany.

ISCIENCE, 2023; 26 (1):

Abstract

THOC5, a member of the THO complex, is essential for the 3'processing of some inducible genes, the export of a subset of mRNAs and stem cell survival.......

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