Synthetic Prostacyclin Agonist Attenuates Pressure-Overloaded Cardiac Fibrosis by Inhibiting FMT

Masada, K; Miyagawa, S; Sakai, Y; Harada, A; Kanaya, T; Sawa, Y

Sawa, Y (corresponding author), Osaka Univ, Dept Cardiovasc Surg, Grad Sch Med, Osaka 5650871, Japan.; Sawa, Y (corresponding author), Osaka Univ, Dept Cardiovasc Surg, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2020; 19 (): 210

Abstract

Fibroblast-to-myofibroblast transition (FMT) is the primary inducer of cardiac fibrosis. ONO-1301, a synthetic prostacyclin agonist, reportedly promot......

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