Catalytic asymmetric and stereodivergent oligonucleotide synthesis

Featherston, AL; Kwon, Y; Pompeo, MM; Engl, OD; Leahy, DK; Miller, SJ

Miller, SJ (corresponding author), Yale Univ, Dept Chem, New Haven, CT 06520 USA.; Leahy, DK (corresponding author), Takeda Pharmaceut Int Co, Proc Chem Dev, Cambridge, MA 02139 USA.; Leahy, DK (corresponding author), Biohaven Pharmaceut, New Haven, CT 06510 USA.

SCIENCE, 2021; 371 (6530): 702

Abstract

We report the catalytic stereocontrolled synthesis of dinucleotides. We have demonstrated, for the first time to our knowledge, that chiral phosphoric......

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