KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors-TORC1/2 Inhibition as Salvage Strategy

Muhlenberg, T; Ketzer, J; Heinrich, MC; Grunewald, S; Marino-Enriquefl, A; Trautmann, M; Hartmann, W; Wardelmann, E; Treckmann, J; Worm, K; Bertram, S; Herold, T; Schildhaus, HU; Glimm, H; Stenzinger, A; Brors, B; Horak, P; Hohenberger, P; Frohling,

Muhlenberg, T; Bauer, S (reprint author), Univ Duisburg Essen, Med Sch, Hufelandstr 55, D-45147 Essen, Germany.

MOLECULAR CANCER THERAPEUTICS, 2019; 18 (11): 1985

Abstract

Sporadic gastrointestinal stromal tumors (GIST), characterized by activating mutations of KIT or PDGFRA, favorably respond to KIT inhibitory treatment......

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