Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD(+)

Babu, D; Morgan, AG; Reiz, B; Whittal, RM; Almas, S; Lacy, P; Siraki, AG

Siraki, AG (reprint author), Univ Alberta, Katz Grp Ctr Pharm & Hlth Res, Fac Pharm & Pharmaceut Sci, Room 2-020H, Edmonton, AB T6G 2E1, Canada.

CHEMICO-BIOLOGICAL INTERACTIONS, 2019; 305 (): 48

Abstract

The formation of isonicotinyl-nicotinamide adenine dinucleotide (INH-NAD(+)) by the mycobacterial catalase-peroxidase enzyme, KatG, was known to be th......

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