Plasma lysosphingolipids in GRN-related diseases: Monitoring lysosomal dysfunction to track disease progression

Khrouf, W; Saracino, D; Rucheton, B; Houot, M; Clot, F; Rinaldi, D; Vitor, J; Huynh, M; Heng, E; Schlemmer, D; Pasquier, F; Deramecourt, V; Auriacombe, S; Azuar, C; Levy, R; Bombois, S; Boutoleau-Brétonnière, C; Pariente, J; Didic, M; Wallon, D; Fluchère, F; Auvin, S; Ben Younes, I; Nadjar, Y; Brice, A; Dubois, B; Bonnefont-Rousselot, D; Le Ber, I; Lamari, F

Lamari, F (通讯作者)，Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Neurometab & Neurodegenerat Unit,DMU Biogem Metab, 47-83 blvd Hop, F-75013 Paris, France.;Le Ber, I (通讯作者)，Hop La Pitie Salpetriere, AP HP, Inst Cerveau Paris ICM, 47-83 Blvd Hop, F-75013 Paris, France.

NEUROBIOLOGY OF DISEASE, 2023; 181 ():

Abstract

GRN mutations are among the main genetic causes of frontotemporal dementia (FTD). Considering the pro-granulin involvement in lysosomal homeostasis, w......

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