Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (epsilon 2/epsilon 3/epsilon 4) and knock-out for the study of APOE biology in health and disease

Schmid, B; Holst, B; Clausen, C; Bahnassawy, L; Reinhardt, P; Bakker, MHM; Diaz-Guerra, E; Vicario, C; Martino-Adami, PV; Thoenes, M; Ramirez, A; Flissbach, K; Grezella, C; Brustle, O; Peitz, M; Ebneth, A; Cabrera-Socorro, A

Cabrera-Socorro, A (corresponding author), Johnson & Johnson, Janssen Res & Dev, Neurosci Therapeut Area, Turnhoutseweg 30, B-2340 Beerse, Belgium.

STEM CELL RESEARCH, 2021; 52 ():

Abstract

APOE genotype is the strongest genetic risk factor for Alzheimer's Disease (AD). The low degree of homology between mouse and human APOE is a concerni......

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