Supersaturated-Silica Lipid Hybrids Improve in Vitro Solubilization of Abiraterone Acetate

Schultz, HB; Joyce, P; Thomas, N; Prestidge, CA

Prestidge, CA (corresponding author), Univ South Australia, Canc Res Inst, Adelaide, SA 5000, Australia.; Prestidge, CA (corresponding author), Univ South Australia, ARC Ctr Excellence Convergent Bionano Sci & Techn, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia.

PHARMACEUTICAL RESEARCH, 2020; 37 (4):

Abstract

Purpose Abiraterone acetate (AbA) is a poorly water-soluble drug with an oral bioavailability of <10% and a significant pharmaceutical food effect.......

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