N-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride

Yokoo, H; Yamamoto, E; Masada, S; Uchiyama, N; Tsuji, G; Hakamatsuka, T; Demizu, Y; Izutsu, KI; Goda, Y

Yamamoto, E (corresponding author), Natl Inst Hlth Sci, Kawasaki Ku, 3-25-26 Tonomachi, Kawasaki, Kanagawa 2109501, Japan.

CHEMICAL & PHARMACEUTICAL BULLETIN, 2021; 69 (9): 872

Abstract

N-Nitrosodimethylamine (NDMA) is a probable human carcinogen. This study investigated the root cause of the presence of NDMA in ranitidine hydrochlori......

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