Next-generation repeat-free FISH probes for DNA amplification in glioblastoma in vivo: Improving patient selection to MDM2-targeted inhibitors

Brunelli, M; Eccher, A; Cima, L; Trippini, T; Pedron, S; Chilosi, M; Barbareschi, M; Scarpa, A; Pinna, G; Cabrini, G; Pilotto, S; Carbognin, L; Bria, E; Tortora, G; Fioravanzo, A; Schiavo, N; Meglio, M; Sava, T; Belli, L; Martignoni, G; Ghimenton, C

Brunelli, M (reprint author), AOUI Hosp Trust Verona, Dept Diagnost & Publ Hlth, FISH Lab, Verona, Italy.; Brunelli, M (reprint author), AOUI Hosp Trust Verona, Dept Diagnost & Publ Hlth, Anat Pathol, Verona, Italy.

CANCER GENETICS, 2017; 210 ( ): 28

Abstract

A next-generation FISH probe mapping to the MDM2 locus-specific region has recently been designed. The level of MDM2 gene amplification (high versus l......

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