Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling

Hao, YY; Chen, PP; Guo, SS; Li, MY; Jin, XL; Zhang, MH; Deng, WH; Li, P; Lei, W; Liang, AB; Qian, WB

Lei, W; Qian, WB (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Coll Med, Dept Hematol, Hangzhou 310009, Peoples R China.;Liang, AB (通讯作者)，Tongji Univ, Tongji Hosp, Dept Hematol, Shanghai 200065, Peoples R China.

FRONTIERS OF MEDICINE, 2023; ():

Abstract

Tumor-derived exosomes (TEXs) enriched in immune suppressive molecules predominantly drive T-cell dysfunction and impair antitumor immunity. Chimeric ......

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