Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases

Miller, JC; Schuler, MA

Schuler, MA (通讯作者),Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61801 USA.;Schuler, MA (通讯作者),Univ Illinois, Dept Biochem, Urbana, IL 61801 USA.;Schuler, MA (通讯作者),Univ Illinois, Dept Plant Biol, Urbana, IL 61801 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2022; 298 (9):

Abstract

Terpene indole alkaloids (TIAs) are plant-derived specialized metabolites with widespread use in medicine. Species-specific pathways derive various TI......

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