Crushing of dolutegravir fixed-dose combination tablets increases dolutegravir exposure

Roskam-Kwint, M; Bollen, P; Colbers, A; Duisenberg-van Essenberg, M; Harbers, V; Burger, D

Colbers, A (reprint author), Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Pharm, Nijmegen, Netherlands.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018; 73 (9): 2430

Abstract

Background: If HIV patients are unconscious or cannot swallow tablets for other reasons, antiretroviral medication is crushed and dissolved prior to a......

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