The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis

Zhou, JX; Wang, X; Wang, M; Chang, YW; Zhang, FX; Ban, ZN; Tang, RF; Gan, QW; Wu, SH; Guo, Y; Zhang, Q; Wang, FY; Zhao, LY; Jing, YD; Qian, WF; Wang, GD; Guo, WX; Yang, CL

Guo, WX; Yang, CL (reprint author), Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China.; Yang, CL (reprint author), Yunnan Univ, Sch Life Sci, State Key Lab Nat Resource Conservat & Utilizat Y, Kunming, Yunnan, P

JOURNAL OF CELL BIOLOGY, 2019; 218 (2): 580

Abstract

Amino acid catabolism is frequently executed in mitochondria; however, it is largely unknown how aberrant amino acid metabolism affects mitochondria. ......

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