Kras(P34R) and Kras(T58I) mutations induce distinct RASopathy phenotypes in mice

Wong, JC; Perez-Mancera, PA; Huang, TQ; Kim, J; Grego-Bessa, J; Alzamora, MD; Kogan, SC; Sharir, A; Keefe, SH; Morales, CE; Schanze, D; Castel, P; Hirose, K; Huang, GN; Zenker, M; Sheppard, D; Klein, OD; Tuveson, DA; Braun, BS; Shannon, K

Shannon, K (corresponding author), Univ Calif San Francisco, Dept Pediat, Helen Diller Family Canc Res Bldg,1450 3rd St, San Francisco, CA 94158 USA.

JCI INSIGHT, 2020; 5 (21):

Abstract

Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of germline KRAS mutations causes developmental disorder......

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