Development of photocontrolled BRD4 PROTACs for tongue squamous cell carcinoma (TSCC)

Li, ZZ; Ma, SY; Yang, XY; Zhang, L; Liang, D; Dong, GP; Du, LP; Lv, ZH; Li, MY

Du, LP; Li, MY (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Pharm, Dept Med Chem,Key Lab Chem Biol MOE, Jinan 250012, Shandong, Peoples R China.; Lv, ZH (corresponding author), Shandong Univ, Shandong Prov ENT Hosp, Cheeloo Coll Med, Dept Head & Neck Surg, Jinan 250022, Shandong, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 222 ():

Abstract

The catalytic properties of small-molecule proteolysis targeting chimeras (PROTACs) may lead to uncontrolled degradation. Therefore, the main disadvan......

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