tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase

Zuko, A; Mallik, M; Thompson, R; Spaulding, EL; Wienand, AR; Been, M; Tadenev, ALD; van Bakel, N; Sijlmans, C; Santos, LA; Bussmann, J; Catinozzi, M; Das, S; Kulshrestha, D; Burgess, RW; Ignatova, Z; Storkebaum, E

Storkebaum, E (corresponding author), Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Mol Neurobiol, Nijmegen, Netherlands.; Storkebaum, E (corresponding author), Radboud Univ Nijmegen, Fac Sci, Nijmegen, Netherlands.; Storkebaum, E (corresponding author), Max Planck Inst Mol Biomed, Mol Neurogenet Lab, Munster, Germany.

SCIENCE, 2021; 373 (6559): 1161

Abstract

Heterozygous mutations in six transfer RNA (tRNA) synthetase genes cause Charcot-Marie-Tooth (CMT) peripheral neuropathy. CMT mutant tRNA synthetases ......

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